Exenatide Ameliorates Inflammatory Response in Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes
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چکیده
منابع مشابه
Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytes.
Activated rheumatoid arthritis fibroblast-like synoviocytes (RAFLSs) play an important role in the initiation and progression of rheumatoid arthritis (RA). Rapid proliferation and defective apoptosis of RAFLSs are two main mechanisms contributing to synovial hyperplasia. Berberine, the major constituent of Coptidis Rhizoma, has been widely used as an antitumor and anti-inflammation agent. Here ...
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Introduction Fibroblast-like synoviocytes (FLS) are key players in the pathogenesis of rheumatoid arthritis (RA). During the onset of the disease, they are transformed into an aggressive phenotype that sustains the joint-destructive infl ammatory environment of RA. This transformation is most likely due to the combination of cytokines, growth factors and cellular interaction, which leads to the...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2019
ISSN: 1521-6543
DOI: 10.1002/iub.2031